DPDPE

[D-Pen2, D-Pen5]-enkephalin

5 Amino Acids · MW: 645.79 Da

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Amino Acids

Molecular Weight

645.79 Da

Half-life

15-60 minutes in plasma

Research Score

4.7

Studies

800

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is DPDPE?

DPDPE is a cyclic enkephalin analog with strong delta-opioid selectivity and a long history in analgesia research. The disulfide-constrained structure makes it a valuable probe for studying receptor selectivity and peptide stability.

Key Benefits & Mechanisms

delta-opioid selectivity

improved conformational stability

analgesic receptor mapping

useful in chronic pain models

Research Summary

DPDPE is widely cited in opioid pharmacology because it helped establish the functional role of delta-opioid receptors in pain control. Its constrained structure is also used to explore how peptide cyclization changes potency, stability, and tissue selectivity.

Related Peptides

Met-enkephalin

Tyr-Gly-Gly-Phe-Met

Met-enkephalin is an endogenous opioid pentapeptide that acts at opioid receptors and produces measurable antinociception in classic pain models. It is one of the foundational peptides used to study endogenous pain-control pathways and enkephalin metabolism.

Pain Management

Leu-enkephalin

Tyr-Gly-Gly-Phe-Leu

Leu-enkephalin is an endogenous enkephalin that binds opioid receptors and has well-characterized antinociceptive effects. It is widely used in research on delta-opioid signaling, peptide metabolism, and pain modulation.

Pain Management

DADLE

[D-Ala2, D-Leu5]-enkephalin

DADLE is a synthetic enkephalin analog designed to improve opioid-receptor activity and analgesic potency relative to natural enkephalins. It is a classic research compound for delta-opioid and spinal analgesia studies.

Pain Management

Endomorphin-1

Tyr-Pro-Trp-Phe-NH2

Endomorphin-1 is an endogenous tetrapeptide with high mu-opioid receptor affinity and potent analgesic activity in laboratory models. It is often studied as a naturally occurring peptide analgesic candidate and as a comparator for synthetic opioid peptides.

Pain Management