DADLE

[D-Ala2, D-Leu5]-enkephalin

5 Amino Acids · MW: 569.67 Da

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Amino Acids

Molecular Weight

569.67 Da

Half-life

5-20 minutes in plasma

Research Score

4.4

Studies

450

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is DADLE?

DADLE is a synthetic enkephalin analog designed to improve opioid-receptor activity and analgesic potency relative to natural enkephalins. It is a classic research compound for delta-opioid and spinal analgesia studies.

Key Benefits & Mechanisms

delta-opioid agonism

enhanced peptide stability

spinal analgesia models

research on tolerance mechanisms

Research Summary

DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.

Related Peptides

Met-enkephalin

Tyr-Gly-Gly-Phe-Met

Met-enkephalin is an endogenous opioid pentapeptide that acts at opioid receptors and produces measurable antinociception in classic pain models. It is one of the foundational peptides used to study endogenous pain-control pathways and enkephalin metabolism.

Pain Management

Leu-enkephalin

Tyr-Gly-Gly-Phe-Leu

Leu-enkephalin is an endogenous enkephalin that binds opioid receptors and has well-characterized antinociceptive effects. It is widely used in research on delta-opioid signaling, peptide metabolism, and pain modulation.

Pain Management

DPDPE

[D-Pen2, D-Pen5]-enkephalin

DPDPE is a cyclic enkephalin analog with strong delta-opioid selectivity and a long history in analgesia research. The disulfide-constrained structure makes it a valuable probe for studying receptor selectivity and peptide stability.

Pain Management

Endomorphin-1

Tyr-Pro-Trp-Phe-NH2

Endomorphin-1 is an endogenous tetrapeptide with high mu-opioid receptor affinity and potent analgesic activity in laboratory models. It is often studied as a naturally occurring peptide analgesic candidate and as a comparator for synthetic opioid peptides.

Pain Management