Endomorphin-1

Tyr-Pro-Trp-Phe-NH2

4 Amino Acids · MW: 610.71 Da

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Amino Acids

Molecular Weight

610.71 Da

Half-life

Minutes in plasma

Research Score

4.3

Studies

600

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is Endomorphin-1?

Endomorphin-1 is an endogenous tetrapeptide with high mu-opioid receptor affinity and potent analgesic activity in laboratory models. It is often studied as a naturally occurring peptide analgesic candidate and as a comparator for synthetic opioid peptides.

Key Benefits & Mechanisms

mu-opioid selectivity

potent antinociception

endogenous peptide scaffold

useful for receptor-discovery studies

Research Summary

Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.

Related Peptides

Met-enkephalin

Tyr-Gly-Gly-Phe-Met

Met-enkephalin is an endogenous opioid pentapeptide that acts at opioid receptors and produces measurable antinociception in classic pain models. It is one of the foundational peptides used to study endogenous pain-control pathways and enkephalin metabolism.

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Leu-enkephalin

Tyr-Gly-Gly-Phe-Leu

Leu-enkephalin is an endogenous enkephalin that binds opioid receptors and has well-characterized antinociceptive effects. It is widely used in research on delta-opioid signaling, peptide metabolism, and pain modulation.

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DADLE

[D-Ala2, D-Leu5]-enkephalin

DADLE is a synthetic enkephalin analog designed to improve opioid-receptor activity and analgesic potency relative to natural enkephalins. It is a classic research compound for delta-opioid and spinal analgesia studies.

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DPDPE

[D-Pen2, D-Pen5]-enkephalin

DPDPE is a cyclic enkephalin analog with strong delta-opioid selectivity and a long history in analgesia research. The disulfide-constrained structure makes it a valuable probe for studying receptor selectivity and peptide stability.

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