Met-enkephalin vs Calcitonin
Head-to-head comparison of Met-enkephalin (Tyr-Gly-Gly-Phe-Met) and Calcitonin (Salmon Calcitonin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Met-enkephalin | Calcitonin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Tyr-Gly-Gly-Phe-Met | Salmon Calcitonin |
| Molecular Weight | 573.67 Da | 3431.9 Da |
| Half-Life | 1-5 minutes in plasma | about 10-15 minutes |
| Amino Acids | 5 | 32 |
| Typical Dose | 0.1-5 ug per animal | 100 IU/day SC or 200 IU/day intranasal |
| Route | Intrathecal / intracerebroventricular | Intranasal/Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 350 |
| Research Status | Pre-clinical | Approved |
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Calcitonin Benefits
- ✓bone pain relief
- ✓short-term analgesic effect
- ✓may reduce opioid requirement
- ✓useful in osteoporotic fracture pain
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Calcitonin Dosing
100 IU subcutaneous daily|200 IU intranasal daily|short-term use in acute pain settings
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Calcitonin Side Effects
- ⚠nausea
- ⚠flushing
- ⚠rhinitis
Research Overview
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
Calcitonin
Calcitonin has been evaluated in randomized trials and reviews for pain associated with vertebral compression fractures and other bone-related conditions. The signal is strongest for short-term analgesia rather than long-term chronic pain control.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.