Calcitonin
Salmon Calcitonin
32 Amino Acids · MW: 3431.9 Da
Amino Acids
32
Molecular Weight
3431.9 Da
Half-life
about 10-15 minutes
Research Score
4.4
Studies
350
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Calcitonin?
A 32-amino-acid peptide hormone used clinically for several skeletal indications and studied for analgesic effects. It has literature support in acute bone pain, vertebral fracture pain, and some neuropathic pain settings.
Key Benefits & Mechanisms
bone pain relief
short-term analgesic effect
may reduce opioid requirement
useful in osteoporotic fracture pain
Research Summary
Calcitonin has been evaluated in randomized trials and reviews for pain associated with vertebral compression fractures and other bone-related conditions. The signal is strongest for short-term analgesia rather than long-term chronic pain control.
Related Peptides
Met-enkephalin
Tyr-Gly-Gly-Phe-Met
Met-enkephalin is an endogenous opioid pentapeptide that acts at opioid receptors and produces measurable antinociception in classic pain models. It is one of the foundational peptides used to study endogenous pain-control pathways and enkephalin metabolism.
Pain ManagementLeu-enkephalin
Tyr-Gly-Gly-Phe-Leu
Leu-enkephalin is an endogenous enkephalin that binds opioid receptors and has well-characterized antinociceptive effects. It is widely used in research on delta-opioid signaling, peptide metabolism, and pain modulation.
Pain ManagementDADLE
[D-Ala2, D-Leu5]-enkephalin
DADLE is a synthetic enkephalin analog designed to improve opioid-receptor activity and analgesic potency relative to natural enkephalins. It is a classic research compound for delta-opioid and spinal analgesia studies.
Pain ManagementDPDPE
[D-Pen2, D-Pen5]-enkephalin
DPDPE is a cyclic enkephalin analog with strong delta-opioid selectivity and a long history in analgesia research. The disulfide-constrained structure makes it a valuable probe for studying receptor selectivity and peptide stability.
Pain Management