Met-enkephalin vs Larazotide
Head-to-head comparison of Met-enkephalin (Tyr-Gly-Gly-Phe-Met) and Larazotide (Larazotide acetate (AT-1001)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Met-enkephalin | Larazotide |
|---|---|---|
| Category | Pain Management | Gastrointestinal |
| Full Name | Tyr-Gly-Gly-Phe-Met | Larazotide acetate (AT-1001) |
| Molecular Weight | 573.67 Da | N/A |
| Half-Life | 1-5 minutes in plasma | short; designed for local gut action |
| Amino Acids | 5 | 8 |
| Typical Dose | 0.1-5 ug per animal | 0.5-4 mg TID (clinical studies) |
| Route | Intrathecal / intracerebroventricular | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 40 |
| Research Status | Pre-clinical | Clinical |
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Research Overview
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
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