Secretin vs Endomorphin-1
Head-to-head comparison of Secretin (Human Secretin) and Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Secretin | Endomorphin-1 |
|---|---|---|
| Category | Gastrointestinal | Pain Management |
| Full Name | Human Secretin | Tyr-Pro-Trp-Phe-NH2 |
| Molecular Weight | 3055.4 Da | 610.71 Da |
| Half-Life | 5-7 minutes | Minutes in plasma |
| Amino Acids | 27 | 4 |
| Typical Dose | 0.2 mcg/kg IV | 0.1-10 ug per animal |
| Route | Intravenous | Intrathecal / subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 600 |
| Research Status | Clinical | Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
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