Secretin vs Met-enkephalin
Head-to-head comparison of Secretin (Human Secretin) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Secretin | Met-enkephalin |
|---|---|---|
| Category | Gastrointestinal | Pain Management |
| Full Name | Human Secretin | Tyr-Gly-Gly-Phe-Met |
| Molecular Weight | 3055.4 Da | 573.67 Da |
| Half-Life | 5-7 minutes | 1-5 minutes in plasma |
| Amino Acids | 27 | 5 |
| Typical Dose | 0.2 mcg/kg IV | 0.1-5 ug per animal |
| Route | Intravenous | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 1200 |
| Research Status | Clinical | Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
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