Secretin vs Leu-enkephalin
Head-to-head comparison of Secretin (Human Secretin) and Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Secretin | Leu-enkephalin |
|---|---|---|
| Category | Gastrointestinal | Pain Management |
| Full Name | Human Secretin | Tyr-Gly-Gly-Phe-Leu |
| Molecular Weight | 3055.4 Da | 555.63 Da |
| Half-Life | 5-7 minutes | 1-5 minutes in plasma |
| Amino Acids | 27 | 5 |
| Typical Dose | 0.2 mcg/kg IV | 0.1-5 ug per animal |
| Route | Intravenous | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 1000 |
| Research Status | Clinical | Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
Leu-enkephalin Benefits
- ✓delta-opioid activity
- ✓endogenous analgesic model
- ✓receptor-selective pharmacology
- ✓nociception pathway research
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
Leu-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
Leu-enkephalin Side Effects
- ⚠sedation
- ⚠constipation-like opioid effects
- ⚠very short plasma stability
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
Leu-enkephalin
Leu-enkephalin is a standard tool in opioid receptor and pain-transmission research because it helps distinguish delta- from mu-preferring signaling. Its research value is high, but its clinical utility is limited by rapid enzymatic breakdown and delivery challenges.
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