Leu-enkephalin vs Teduglutide
Head-to-head comparison of Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and Teduglutide (Teduglutide (glycyl-2 human glucagon-like peptide-2 analog)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Leu-enkephalin | Teduglutide |
|---|---|---|
| Category | Pain Management | Gastrointestinal |
| Full Name | Tyr-Gly-Gly-Phe-Leu | Teduglutide (glycyl-2 human glucagon-like peptide-2 analog) |
| Molecular Weight | 555.63 Da | 3752 Da |
| Half-Life | 1-5 minutes in plasma | approximately 2-3 hours |
| Amino Acids | 5 | 33 |
| Typical Dose | 0.1-5 ug per animal | 0.05 mg/kg/day |
| Route | Intrathecal / intracerebroventricular | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 1000 | 300 |
| Research Status | Pre-clinical | Clinical |
Leu-enkephalin Benefits
- ✓delta-opioid activity
- ✓endogenous analgesic model
- ✓receptor-selective pharmacology
- ✓nociception pathway research
Teduglutide Benefits
- ✓mucosal-growth
- ✓absorption-support
- ✓barrier-repair
- ✓intestinal-adaptation
Leu-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Teduglutide Dosing
0.05 mg/kg once daily subcutaneous injection|chronic maintenance dosing in approved use|monitor fluid status and intestinal anatomy
Leu-enkephalin Side Effects
- ⚠sedation
- ⚠constipation-like opioid effects
- ⚠very short plasma stability
Teduglutide Side Effects
- ⚠abdominal pain
- ⚠fluid retention
- ⚠polyp/neoplasia monitoring needed
Research Overview
Leu-enkephalin
Leu-enkephalin is a standard tool in opioid receptor and pain-transmission research because it helps distinguish delta- from mu-preferring signaling. Its research value is high, but its clinical utility is limited by rapid enzymatic breakdown and delivery challenges.
Teduglutide
Teduglutide has robust clinical evidence showing improved intestinal absorption and reduced parenteral nutrition dependence in short bowel syndrome. Its mechanism, via GLP-2 receptor activation, makes it highly relevant to mucosal healing and intestinal adaptation research.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.