Secretin vs DADLE
Head-to-head comparison of Secretin (Human Secretin) and DADLE ([D-Ala2, D-Leu5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
| Property | Secretin | DADLE |
|---|---|---|
| Category | Gastrointestinal | Pain Management |
| Full Name | Human Secretin | [D-Ala2, D-Leu5]-enkephalin |
| Molecular Weight | 3055.4 Da | 569.67 Da |
| Half-Life | 5-7 minutes | 5-20 minutes in plasma |
| Amino Acids | 27 | 5 |
| Typical Dose | 0.2 mcg/kg IV | 0.01-2 ug per animal |
| Route | Intravenous | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 800 | 450 |
| Research Status | Clinical | Pre-clinical |
Secretin Benefits
- ✓stimulates-pancreatic-secretion
- ✓supports-bicarbonate-release
- ✓aids-duodenal-pH-control
- ✓helps-digestive-coordination
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
Secretin Dosing
0.2 mcg/kg IV diagnostic dose|research infusion protocols|short bolus administration
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
Secretin Side Effects
- ⚠flushing
- ⚠nausea
- ⚠abdominal-cramping
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Research Overview
Secretin
Secretin is a classic GI hormone with extensive physiology literature and established diagnostic use. It remains important for studying pancreatic secretory function, biliary responses, and duodenal feedback.
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
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