DADLE vs Larazotide
Head-to-head comparison of DADLE ([D-Ala2, D-Leu5]-enkephalin) and Larazotide (Larazotide acetate (AT-1001)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | DADLE | Larazotide |
|---|---|---|
| Category | Pain Management | Gastrointestinal |
| Full Name | [D-Ala2, D-Leu5]-enkephalin | Larazotide acetate (AT-1001) |
| Molecular Weight | 569.67 Da | N/A |
| Half-Life | 5-20 minutes in plasma | short; designed for local gut action |
| Amino Acids | 5 | 8 |
| Typical Dose | 0.01-2 ug per animal | 0.5-4 mg TID (clinical studies) |
| Route | Intrathecal / intracerebroventricular | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 450 | 40 |
| Research Status | Pre-clinical | Clinical |
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
Larazotide Benefits
- ✓tight-junction-support
- ✓reduced-permeability
- ✓symptom-reduction
- ✓barrier-protection
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
Larazotide Dosing
0.5-4 mg orally before meals in clinical trials|typically three times daily|short-course or chronic study protocols
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Larazotide Side Effects
- ⚠headache
- ⚠nausea
- ⚠abdominal discomfort
Research Overview
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
Larazotide
Clinical and translational studies suggest larazotide can reduce antigen passage across the epithelium and improve gut barrier function. It is one of the better-known peptides for intestinal permeability and barrier-focused gastrointestinal therapy.
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