DADLE vs Met-enkephalin
Head-to-head comparison of DADLE ([D-Ala2, D-Leu5]-enkephalin) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | DADLE | Met-enkephalin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | [D-Ala2, D-Leu5]-enkephalin | Tyr-Gly-Gly-Phe-Met |
| Molecular Weight | 569.67 Da | 573.67 Da |
| Half-Life | 5-20 minutes in plasma | 1-5 minutes in plasma |
| Amino Acids | 5 | 5 |
| Typical Dose | 0.01-2 ug per animal | 0.1-5 ug per animal |
| Route | Intrathecal / intracerebroventricular | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 450 | 1200 |
| Research Status | Pre-clinical | Pre-clinical |
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Research Overview
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
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