DADLE vs Endomorphin-1
Head-to-head comparison of DADLE ([D-Ala2, D-Leu5]-enkephalin) and Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | DADLE | Endomorphin-1 |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | [D-Ala2, D-Leu5]-enkephalin | Tyr-Pro-Trp-Phe-NH2 |
| Molecular Weight | 569.67 Da | 610.71 Da |
| Half-Life | 5-20 minutes in plasma | Minutes in plasma |
| Amino Acids | 5 | 4 |
| Typical Dose | 0.01-2 ug per animal | 0.1-10 ug per animal |
| Route | Intrathecal / intracerebroventricular | Intrathecal / subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 450 | 600 |
| Research Status | Pre-clinical | Pre-clinical |
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Research Overview
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
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