Endomorphin-1 vs Cosyntropin
Head-to-head comparison of Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and Cosyntropin (Cosyntropin (ACTH 1-24)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endomorphin-1 | Cosyntropin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Tyr-Pro-Trp-Phe-NH2 | Cosyntropin (ACTH 1-24) |
| Molecular Weight | 610.71 Da | 2933.3 Da |
| Half-Life | Minutes in plasma | ~10 min |
| Amino Acids | 4 | 24 |
| Typical Dose | 0.1-10 ug per animal | 0.25 mg IV/IM diagnostic dose|off-label headache protocols vary |
| Route | Intrathecal / subcutaneous | IV|IM |
| Purity | ≥98% | ≥98% |
| Studies Count | 600 | 61 |
| Research Status | Pre-clinical | Clinical research |
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Cosyntropin Benefits
- ✓refractory migraine
- ✓anti-inflammatory signaling
- ✓headache rescue research
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Cosyntropin Dosing
0.25 mg IV/IM|1 mg IV/IM
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Cosyntropin Side Effects
- ⚠flushing
- ⚠nausea
Research Overview
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
Cosyntropin
Cosyntropin is not a standard pain drug, but it appears in headache literature because ACTH analogs can help some patients with difficult migraine attacks. The analgesic rationale is partly tied to steroidogenic and anti-inflammatory effects.
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