Endomorphin-1 vs DPDPE
Head-to-head comparison of Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and DPDPE ([D-Pen2, D-Pen5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endomorphin-1 | DPDPE |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Tyr-Pro-Trp-Phe-NH2 | [D-Pen2, D-Pen5]-enkephalin |
| Molecular Weight | 610.71 Da | 645.79 Da |
| Half-Life | Minutes in plasma | 15-60 minutes in plasma |
| Amino Acids | 4 | 5 |
| Typical Dose | 0.1-10 ug per animal | 0.01-1 ug per animal |
| Route | Intrathecal / subcutaneous | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 600 | 800 |
| Research Status | Pre-clinical | Pre-clinical |
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
DPDPE Benefits
- ✓delta-opioid selectivity
- ✓improved conformational stability
- ✓analgesic receptor mapping
- ✓useful in chronic pain models
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
DPDPE Dosing
Intrathecal 0.01-1 ug per animal|Intracerebroventricular 0.01-0.5 ug per animal|In vitro 0.1-20 nM
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
DPDPE Side Effects
- ⚠sedation
- ⚠nausea-like opioid effects
- ⚠tolerance with repeated dosing
Research Overview
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
DPDPE
DPDPE is widely cited in opioid pharmacology because it helped establish the functional role of delta-opioid receptors in pain control. Its constrained structure is also used to explore how peptide cyclization changes potency, stability, and tissue selectivity.
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