Endomorphin-1 vs DADLE
Head-to-head comparison of Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and DADLE ([D-Ala2, D-Leu5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endomorphin-1 | DADLE |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Tyr-Pro-Trp-Phe-NH2 | [D-Ala2, D-Leu5]-enkephalin |
| Molecular Weight | 610.71 Da | 569.67 Da |
| Half-Life | Minutes in plasma | 5-20 minutes in plasma |
| Amino Acids | 4 | 5 |
| Typical Dose | 0.1-10 ug per animal | 0.01-2 ug per animal |
| Route | Intrathecal / subcutaneous | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 600 | 450 |
| Research Status | Pre-clinical | Pre-clinical |
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Research Overview
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
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