Cosyntropin

Cosyntropin (ACTH 1-24)

24 Amino Acids · MW: 2933.3 Da

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Amino Acids

Molecular Weight

2933.3 Da

Half-life

~10 min

Research Score

5.0

Studies

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is Cosyntropin?

A synthetic 24-amino-acid fragment of ACTH used clinically in adrenal testing. It has also been used off-label in refractory migraine/status migrainosus, making it a real peptide of interest in headache care.

Key Benefits & Mechanisms

refractory migraine

anti-inflammatory signaling

headache rescue research

Research Summary

Cosyntropin is not a standard pain drug, but it appears in headache literature because ACTH analogs can help some patients with difficult migraine attacks. The analgesic rationale is partly tied to steroidogenic and anti-inflammatory effects.

Related Peptides

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Tyr-Gly-Gly-Phe-Met

Met-enkephalin is an endogenous opioid pentapeptide that acts at opioid receptors and produces measurable antinociception in classic pain models. It is one of the foundational peptides used to study endogenous pain-control pathways and enkephalin metabolism.

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Leu-enkephalin

Tyr-Gly-Gly-Phe-Leu

Leu-enkephalin is an endogenous enkephalin that binds opioid receptors and has well-characterized antinociceptive effects. It is widely used in research on delta-opioid signaling, peptide metabolism, and pain modulation.

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DADLE

[D-Ala2, D-Leu5]-enkephalin

DADLE is a synthetic enkephalin analog designed to improve opioid-receptor activity and analgesic potency relative to natural enkephalins. It is a classic research compound for delta-opioid and spinal analgesia studies.

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DPDPE

[D-Pen2, D-Pen5]-enkephalin

DPDPE is a cyclic enkephalin analog with strong delta-opioid selectivity and a long history in analgesia research. The disulfide-constrained structure makes it a valuable probe for studying receptor selectivity and peptide stability.

Pain Management