Endomorphin-1 vs Neurotensin
Head-to-head comparison of Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and Neurotensin (Neurotensin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endomorphin-1 | Neurotensin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Tyr-Pro-Trp-Phe-NH2 | Neurotensin |
| Molecular Weight | 610.71 Da | 1672.94 |
| Half-Life | Minutes in plasma | minutes |
| Amino Acids | 4 | 13 |
| Typical Dose | 0.1-10 ug per animal | N/A|N/A |
| Route | Intrathecal / subcutaneous | Intranasal/experimental injection |
| Purity | ≥98% | ≥98% |
| Studies Count | 600 | 81 |
| Research Status | Pre-clinical | Pre-clinical |
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Neurotensin Benefits
- ✓antinociceptive signaling
- ✓descending pain modulation
- ✓preclinical pain research
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Neurotensin Dosing
N/A|N/A
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Neurotensin Side Effects
- ⚠hypotension
- ⚠nausea
- ⚠hypothermia
Research Overview
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
Neurotensin
Neurotensin has reproducible analgesic and neuromodulatory effects in preclinical studies, especially in inflammatory and neuropathic pain paradigms. It is not a standard clinical analgesic, but it is a real non-opioid peptide with pain-relevant biology.
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