Neurotensin

13 Amino Acids · MW: 1672.94

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Amino Acids

Molecular Weight

1672.94

Half-life

minutes

Research Score

4.1

Studies

Storage

Store lyophilized at -20°C, reconstituted at 2-8°C

What is Neurotensin?

Endogenous 13-amino-acid neuropeptide with antinociceptive activity in several pain models. It modulates dopamine, glutamate, and inflammatory pathways that are relevant to pain processing.

Key Benefits & Mechanisms

antinociceptive signaling

descending pain modulation

preclinical pain research

Research Summary

Neurotensin has reproducible analgesic and neuromodulatory effects in preclinical studies, especially in inflammatory and neuropathic pain paradigms. It is not a standard clinical analgesic, but it is a real non-opioid peptide with pain-relevant biology.

Related Peptides

Met-enkephalin

Tyr-Gly-Gly-Phe-Met

Met-enkephalin is an endogenous opioid pentapeptide that acts at opioid receptors and produces measurable antinociception in classic pain models. It is one of the foundational peptides used to study endogenous pain-control pathways and enkephalin metabolism.

Pain Management

Leu-enkephalin

Tyr-Gly-Gly-Phe-Leu

Leu-enkephalin is an endogenous enkephalin that binds opioid receptors and has well-characterized antinociceptive effects. It is widely used in research on delta-opioid signaling, peptide metabolism, and pain modulation.

Pain Management

DADLE

[D-Ala2, D-Leu5]-enkephalin

DADLE is a synthetic enkephalin analog designed to improve opioid-receptor activity and analgesic potency relative to natural enkephalins. It is a classic research compound for delta-opioid and spinal analgesia studies.

Pain Management

DPDPE

[D-Pen2, D-Pen5]-enkephalin

DPDPE is a cyclic enkephalin analog with strong delta-opioid selectivity and a long history in analgesia research. The disulfide-constrained structure makes it a valuable probe for studying receptor selectivity and peptide stability.

Pain Management