Met-enkephalin vs Neurotensin
Head-to-head comparison of Met-enkephalin (Tyr-Gly-Gly-Phe-Met) and Neurotensin (Neurotensin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Met-enkephalin | Neurotensin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Tyr-Gly-Gly-Phe-Met | Neurotensin |
| Molecular Weight | 573.67 Da | 1672.94 |
| Half-Life | 1-5 minutes in plasma | minutes |
| Amino Acids | 5 | 13 |
| Typical Dose | 0.1-5 ug per animal | N/A|N/A |
| Route | Intrathecal / intracerebroventricular | Intranasal/experimental injection |
| Purity | ≥98% | ≥98% |
| Studies Count | 1200 | 81 |
| Research Status | Pre-clinical | Pre-clinical |
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Neurotensin Benefits
- ✓antinociceptive signaling
- ✓descending pain modulation
- ✓preclinical pain research
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Neurotensin Dosing
N/A|N/A
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Neurotensin Side Effects
- ⚠hypotension
- ⚠nausea
- ⚠hypothermia
Research Overview
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
Neurotensin
Neurotensin has reproducible analgesic and neuromodulatory effects in preclinical studies, especially in inflammatory and neuropathic pain paradigms. It is not a standard clinical analgesic, but it is a real non-opioid peptide with pain-relevant biology.
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