Endomorphin-1 vs Teduglutide
Head-to-head comparison of Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and Teduglutide (Teduglutide (glycyl-2 human glucagon-like peptide-2 analog)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Endomorphin-1 | Teduglutide |
|---|---|---|
| Category | Pain Management | Gastrointestinal |
| Full Name | Tyr-Pro-Trp-Phe-NH2 | Teduglutide (glycyl-2 human glucagon-like peptide-2 analog) |
| Molecular Weight | 610.71 Da | 3752 Da |
| Half-Life | Minutes in plasma | approximately 2-3 hours |
| Amino Acids | 4 | 33 |
| Typical Dose | 0.1-10 ug per animal | 0.05 mg/kg/day |
| Route | Intrathecal / subcutaneous | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 600 | 300 |
| Research Status | Pre-clinical | Clinical |
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Teduglutide Benefits
- ✓mucosal-growth
- ✓absorption-support
- ✓barrier-repair
- ✓intestinal-adaptation
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Teduglutide Dosing
0.05 mg/kg once daily subcutaneous injection|chronic maintenance dosing in approved use|monitor fluid status and intestinal anatomy
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Teduglutide Side Effects
- ⚠abdominal pain
- ⚠fluid retention
- ⚠polyp/neoplasia monitoring needed
Research Overview
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
Teduglutide
Teduglutide has robust clinical evidence showing improved intestinal absorption and reduced parenteral nutrition dependence in short bowel syndrome. Its mechanism, via GLP-2 receptor activation, makes it highly relevant to mucosal healing and intestinal adaptation research.
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