Neurotensin vs Endomorphin-1
Head-to-head comparison of Neurotensin (Neurotensin) and Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neurotensin | Endomorphin-1 |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Neurotensin | Tyr-Pro-Trp-Phe-NH2 |
| Molecular Weight | 1672.94 | 610.71 Da |
| Half-Life | minutes | Minutes in plasma |
| Amino Acids | 13 | 4 |
| Typical Dose | N/A|N/A | 0.1-10 ug per animal |
| Route | Intranasal/experimental injection | Intrathecal / subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 81 | 600 |
| Research Status | Pre-clinical | Pre-clinical |
Neurotensin Benefits
- ✓antinociceptive signaling
- ✓descending pain modulation
- ✓preclinical pain research
Endomorphin-1 Benefits
- ✓mu-opioid selectivity
- ✓potent antinociception
- ✓endogenous peptide scaffold
- ✓useful for receptor-discovery studies
Neurotensin Dosing
N/A|N/A
Endomorphin-1 Dosing
Intrathecal 0.1-10 ug per animal|Subcutaneous 0.1-5 ug per animal|In vitro 0.1-100 nM
Neurotensin Side Effects
- ⚠hypotension
- ⚠nausea
- ⚠hypothermia
Endomorphin-1 Side Effects
- ⚠respiratory depression at high exposure
- ⚠sedation
- ⚠tolerance and dependence potential
Research Overview
Neurotensin
Neurotensin has reproducible analgesic and neuromodulatory effects in preclinical studies, especially in inflammatory and neuropathic pain paradigms. It is not a standard clinical analgesic, but it is a real non-opioid peptide with pain-relevant biology.
Endomorphin-1
Endomorphin-1 is a key research peptide in studies of endogenous mu-opioid signaling and spinal analgesia. Like other peptide analgesics, its main translational hurdles are enzymatic instability, limited oral bioavailability, and delivery across barriers.
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