Neurotensin vs DADLE
Head-to-head comparison of Neurotensin (Neurotensin) and DADLE ([D-Ala2, D-Leu5]-enkephalin) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neurotensin | DADLE |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Neurotensin | [D-Ala2, D-Leu5]-enkephalin |
| Molecular Weight | 1672.94 | 569.67 Da |
| Half-Life | minutes | 5-20 minutes in plasma |
| Amino Acids | 13 | 5 |
| Typical Dose | N/A|N/A | 0.01-2 ug per animal |
| Route | Intranasal/experimental injection | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 81 | 450 |
| Research Status | Pre-clinical | Pre-clinical |
Neurotensin Benefits
- ✓antinociceptive signaling
- ✓descending pain modulation
- ✓preclinical pain research
DADLE Benefits
- ✓delta-opioid agonism
- ✓enhanced peptide stability
- ✓spinal analgesia models
- ✓research on tolerance mechanisms
Neurotensin Dosing
N/A|N/A
DADLE Dosing
Intrathecal 0.01-2 ug per animal|Intracerebroventricular 0.01-1 ug per animal|In vitro 0.1-50 nM
Neurotensin Side Effects
- ⚠hypotension
- ⚠nausea
- ⚠hypothermia
DADLE Side Effects
- ⚠sedation
- ⚠motor suppression at higher doses
- ⚠opioid tolerance with repeated exposure
Research Overview
Neurotensin
Neurotensin has reproducible analgesic and neuromodulatory effects in preclinical studies, especially in inflammatory and neuropathic pain paradigms. It is not a standard clinical analgesic, but it is a real non-opioid peptide with pain-relevant biology.
DADLE
DADLE has been studied for analgesic, neuroprotective, and receptor-selective opioid effects in animal and tissue models. It remains important as a mechanistic probe because it is more stable than endogenous enkephalins but still peptide-like in its delivery constraints.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.