Neurotensin vs Met-enkephalin
Head-to-head comparison of Neurotensin (Neurotensin) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neurotensin | Met-enkephalin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Neurotensin | Tyr-Gly-Gly-Phe-Met |
| Molecular Weight | 1672.94 | 573.67 Da |
| Half-Life | minutes | 1-5 minutes in plasma |
| Amino Acids | 13 | 5 |
| Typical Dose | N/A|N/A | 0.1-5 ug per animal |
| Route | Intranasal/experimental injection | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 81 | 1200 |
| Research Status | Pre-clinical | Pre-clinical |
Neurotensin Benefits
- ✓antinociceptive signaling
- ✓descending pain modulation
- ✓preclinical pain research
Met-enkephalin Benefits
- ✓endogenous opioid signaling
- ✓analgesic reference ligand
- ✓spinal antinociception
- ✓neurochemical pain-pathway probe
Neurotensin Dosing
N/A|N/A
Met-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Neurotensin Side Effects
- ⚠hypotension
- ⚠nausea
- ⚠hypothermia
Met-enkephalin Side Effects
- ⚠sedation at higher exposure
- ⚠constipation-like opioid effects
- ⚠rapid enzymatic degradation
Research Overview
Neurotensin
Neurotensin has reproducible analgesic and neuromodulatory effects in preclinical studies, especially in inflammatory and neuropathic pain paradigms. It is not a standard clinical analgesic, but it is a real non-opioid peptide with pain-relevant biology.
Met-enkephalin
Met-enkephalin has been extensively used in receptor pharmacology and nociception studies to map mu and delta opioid biology. The main limitation in translational work is very short half-life from peptidase cleavage and poor systemic stability.
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