Neurotensin vs Leu-enkephalin
Head-to-head comparison of Neurotensin (Neurotensin) and Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Neurotensin | Leu-enkephalin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Neurotensin | Tyr-Gly-Gly-Phe-Leu |
| Molecular Weight | 1672.94 | 555.63 Da |
| Half-Life | minutes | 1-5 minutes in plasma |
| Amino Acids | 13 | 5 |
| Typical Dose | N/A|N/A | 0.1-5 ug per animal |
| Route | Intranasal/experimental injection | Intrathecal / intracerebroventricular |
| Purity | ≥98% | ≥98% |
| Studies Count | 81 | 1000 |
| Research Status | Pre-clinical | Pre-clinical |
Neurotensin Benefits
- ✓antinociceptive signaling
- ✓descending pain modulation
- ✓preclinical pain research
Leu-enkephalin Benefits
- ✓delta-opioid activity
- ✓endogenous analgesic model
- ✓receptor-selective pharmacology
- ✓nociception pathway research
Neurotensin Dosing
N/A|N/A
Leu-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Neurotensin Side Effects
- ⚠hypotension
- ⚠nausea
- ⚠hypothermia
Leu-enkephalin Side Effects
- ⚠sedation
- ⚠constipation-like opioid effects
- ⚠very short plasma stability
Research Overview
Neurotensin
Neurotensin has reproducible analgesic and neuromodulatory effects in preclinical studies, especially in inflammatory and neuropathic pain paradigms. It is not a standard clinical analgesic, but it is a real non-opioid peptide with pain-relevant biology.
Leu-enkephalin
Leu-enkephalin is a standard tool in opioid receptor and pain-transmission research because it helps distinguish delta- from mu-preferring signaling. Its research value is high, but its clinical utility is limited by rapid enzymatic breakdown and delivery challenges.
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