Leu-enkephalin vs Cosyntropin
Head-to-head comparison of Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and Cosyntropin (Cosyntropin (ACTH 1-24)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Leu-enkephalin | Cosyntropin |
|---|---|---|
| Category | Pain Management | Pain Management |
| Full Name | Tyr-Gly-Gly-Phe-Leu | Cosyntropin (ACTH 1-24) |
| Molecular Weight | 555.63 Da | 2933.3 Da |
| Half-Life | 1-5 minutes in plasma | ~10 min |
| Amino Acids | 5 | 24 |
| Typical Dose | 0.1-5 ug per animal | 0.25 mg IV/IM diagnostic dose|off-label headache protocols vary |
| Route | Intrathecal / intracerebroventricular | IV|IM |
| Purity | ≥98% | ≥98% |
| Studies Count | 1000 | 61 |
| Research Status | Pre-clinical | Clinical research |
Leu-enkephalin Benefits
- ✓delta-opioid activity
- ✓endogenous analgesic model
- ✓receptor-selective pharmacology
- ✓nociception pathway research
Cosyntropin Benefits
- ✓refractory migraine
- ✓anti-inflammatory signaling
- ✓headache rescue research
Leu-enkephalin Dosing
Intrathecal 0.1-5 ug per animal|Intracerebroventricular 0.1-2 ug per animal|In vitro 1-100 nM
Cosyntropin Dosing
0.25 mg IV/IM|1 mg IV/IM
Leu-enkephalin Side Effects
- ⚠sedation
- ⚠constipation-like opioid effects
- ⚠very short plasma stability
Cosyntropin Side Effects
- ⚠flushing
- ⚠nausea
Research Overview
Leu-enkephalin
Leu-enkephalin is a standard tool in opioid receptor and pain-transmission research because it helps distinguish delta- from mu-preferring signaling. Its research value is high, but its clinical utility is limited by rapid enzymatic breakdown and delivery challenges.
Cosyntropin
Cosyntropin is not a standard pain drug, but it appears in headache literature because ACTH analogs can help some patients with difficult migraine attacks. The analgesic rationale is partly tied to steroidogenic and anti-inflammatory effects.
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