MK-677 vs C-peptide
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and C-peptide (Connecting peptide (C-peptide)) — benefits, dosing, side effects, research data, and where to buy.
| Property | MK-677 | C-peptide |
|---|---|---|
| Category | Growth Hormone | Pain Management |
| Full Name | Ibutamoren Mesylate (MK-677) | Connecting peptide (C-peptide) |
| Molecular Weight | 528.662 g/mol | 3020.3 Da |
| Half-Life | ~24 hours | ~20-30 min |
| Amino Acids | Non-peptide compound | 31 |
| Typical Dose | — | no approved analgesic dose|research-only |
| Route | — | IV|subQ |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 46 |
| Research Status | Active Research | Pre-clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
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