MK-677
Ibutamoren Mesylate (MK-677)
Non-peptide compound Amino Acids · MW: 528.662 g/mol
Amino Acids
Non-peptide compound
Molecular Weight
528.662 g/mol
Half-life
~24 hours
Research Score
88.0
Studies
120
Storage
Room temperature, protect from moisture
What is MK-677?
MK-677 is a potent oral growth hormone secretagogue that mimics ghrelin, producing sustained 24-hour elevations in GH and IGF-1 without suppressing natural production.
Key Benefits & Mechanisms
Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Research Summary
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Related Peptides
Ipamorelin
Growth Hormone Secretagogue
Ipamorelin is a selective growth hormone secretagogue that stimulates natural GH release without significantly affecting cortisol or prolactin levels. It is considered one of the safest and most selective GHRPs available.
PerformanceCJC-1295
Growth Hormone Releasing Hormone Analog
CJC-1295 is a modified GHRH analog with an extended half-life due to Drug Affinity Complex (DAC) technology. It promotes sustained, pulsatile GH release, improving body composition, recovery, and sleep quality.
PerformanceIbutamoren
Ibutamoren mesylate (MK-677)
Ibutamoren is an orally active ghrelin receptor agonist that increases pulsatile growth hormone and IGF-1 secretion. It has been studied for effects on lean mass, recovery, and age-related anabolic support.
Growth HormoneAnamorelin
Anamorelin hydrochloride (ONO-7643)
Anamorelin is a selective ghrelin receptor agonist developed to stimulate appetite and growth hormone signaling. It has been investigated primarily in cancer cachexia and other wasting states.
Growth Hormone