C-peptide vs L-692,429
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and L-692,429 (L-692,429) — benefits, dosing, side effects, research data, and where to buy.
| Property | C-peptide | L-692,429 |
|---|---|---|
| Category | Pain Management | Growth Hormone |
| Full Name | Connecting peptide (C-peptide) | L-692,429 |
| Molecular Weight | 3020.3 Da | N/A |
| Half-Life | ~20-30 min | unknown / study-dependent |
| Amino Acids | 31 | N/A |
| Typical Dose | no approved analgesic dose|research-only | 0.03-0.1 mg/kg |
| Route | IV|subQ | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 30 |
| Research Status | Pre-clinical | Pre-clinical |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
L-692,429 Benefits
- ✓potent GHSR agonism
- ✓oral bioactivity in models
- ✓validates ghrelin pathway
- ✓useful research probe
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
L-692,429 Dosing
0.03-0.1 mg/kg in early studies|single oral or short-course research dosing|serial GH sampling recommended
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
L-692,429 Side Effects
- ⚠increased appetite
- ⚠glucose intolerance
- ⚠transient prolactin changes
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
L-692,429
L-692,429 was important in early GH secretagogue research because it showed that nonpeptide molecules could trigger robust GH release. It remains a classic tool compound for studying receptor-mediated GH pulsatility and appetite signaling.
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