C-peptide vs Ibutamoren
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and Ibutamoren (Ibutamoren mesylate (MK-677)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | C-peptide | Ibutamoren |
|---|---|---|
| Category | Pain Management | Growth Hormone |
| Full Name | Connecting peptide (C-peptide) | Ibutamoren mesylate (MK-677) |
| Molecular Weight | 3020.3 Da | N/A |
| Half-Life | ~20-30 min | about 24 hours |
| Amino Acids | 31 | N/A |
| Typical Dose | no approved analgesic dose|research-only | 10-25 mg/day |
| Route | IV|subQ | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 180 |
| Research Status | Pre-clinical | Clinical |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
Ibutamoren Benefits
- ✓raises GH/IGF-1
- ✓increases appetite
- ✓supports lean mass retention
- ✓oral non-peptide secretagogue
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
Ibutamoren Dosing
10-25 mg orally once daily|take consistently at the same time each day|monitor fasting glucose and edema in longer studies
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
Ibutamoren Side Effects
- ⚠increased appetite
- ⚠water retention/edema
- ⚠somnolence or lethargy
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
Ibutamoren
Clinical studies show oral ibutamoren reliably elevates GH and IGF-1 over 24 hours with once-daily dosing. Body composition and appetite effects vary by population, and development has been limited by metabolic side effects.
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