Ibutamoren vs hGHRH(1-32)NH2
Head-to-head comparison of Ibutamoren (Ibutamoren mesylate (MK-677)) and hGHRH(1-32)NH2 (Human growth hormone-releasing factor (1-32) amide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Ibutamoren | hGHRH(1-32)NH2 |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Ibutamoren mesylate (MK-677) | Human growth hormone-releasing factor (1-32) amide |
| Molecular Weight | N/A | N/A |
| Half-Life | about 24 hours | 5-15 minutes |
| Amino Acids | N/A | 32 |
| Typical Dose | 10-25 mg/day | 0.1-1 mcg/kg |
| Route | Oral | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 50 |
| Research Status | Clinical | Clinical Research |
Ibutamoren Benefits
- ✓raises GH/IGF-1
- ✓increases appetite
- ✓supports lean mass retention
- ✓oral non-peptide secretagogue
hGHRH(1-32)NH2 Benefits
- ✓GH pulse induction
- ✓core-sequence testing
- ✓receptor signaling studies
- ✓protease-resistance comparisons
Ibutamoren Dosing
10-25 mg orally once daily|take consistently at the same time each day|monitor fasting glucose and edema in longer studies
hGHRH(1-32)NH2 Dosing
0.1-1 mcg/kg SC or IV bolus|acute GH-response testing with timed blood draws|pulsatile dosing in receptor studies
Ibutamoren Side Effects
- ⚠increased appetite
- ⚠water retention/edema
- ⚠somnolence or lethargy
hGHRH(1-32)NH2 Side Effects
- ⚠headache
- ⚠flushing
- ⚠injection-site irritation
Research Overview
Ibutamoren
Clinical studies show oral ibutamoren reliably elevates GH and IGF-1 over 24 hours with once-daily dosing. Body composition and appetite effects vary by population, and development has been limited by metabolic side effects.
hGHRH(1-32)NH2
Human GHRF(1-32)NH2 is used in basic and translational studies to evaluate how the active N-terminal region of GHRH drives pituitary hormone release. It helps define the lower bound of sequence length needed for meaningful biological activity.
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