C-peptide vs Macimorelin
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | C-peptide | Macimorelin |
|---|---|---|
| Category | Pain Management | Growth Hormone |
| Full Name | Connecting peptide (C-peptide) | Macimorelin acetate (AEZS-130) |
| Molecular Weight | 3020.3 Da | N/A |
| Half-Life | ~20-30 min | about 4-6 hours |
| Amino Acids | 31 | N/A |
| Typical Dose | no approved analgesic dose|research-only | 0.5 mg/kg single oral dose |
| Route | IV|subQ | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 120 |
| Research Status | Pre-clinical | Clinical |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
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