C-peptide
Connecting peptide (C-peptide)
31 Amino Acids · MW: 3020.3 Da
Amino Acids
31
Molecular Weight
3020.3 Da
Half-life
~20-30 min
Research Score
5.0
Studies
46
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is C-peptide?
A 31-amino-acid peptide released with insulin from proinsulin processing. It has been studied in diabetic neuropathy for nerve-conduction and symptom improvements, making it relevant to neuropathic pain research.
Key Benefits & Mechanisms
diabetic neuropathy research
nerve function support
possible analgesic effect
Research Summary
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
Related Peptides
Met-enkephalin
Tyr-Gly-Gly-Phe-Met
Met-enkephalin is an endogenous opioid pentapeptide that acts at opioid receptors and produces measurable antinociception in classic pain models. It is one of the foundational peptides used to study endogenous pain-control pathways and enkephalin metabolism.
Pain ManagementLeu-enkephalin
Tyr-Gly-Gly-Phe-Leu
Leu-enkephalin is an endogenous enkephalin that binds opioid receptors and has well-characterized antinociceptive effects. It is widely used in research on delta-opioid signaling, peptide metabolism, and pain modulation.
Pain ManagementDADLE
[D-Ala2, D-Leu5]-enkephalin
DADLE is a synthetic enkephalin analog designed to improve opioid-receptor activity and analgesic potency relative to natural enkephalins. It is a classic research compound for delta-opioid and spinal analgesia studies.
Pain ManagementDPDPE
[D-Pen2, D-Pen5]-enkephalin
DPDPE is a cyclic enkephalin analog with strong delta-opioid selectivity and a long history in analgesia research. The disulfide-constrained structure makes it a valuable probe for studying receptor selectivity and peptide stability.
Pain Management