Ibutamoren vs hGHRH(1-44)
Head-to-head comparison of Ibutamoren (Ibutamoren mesylate (MK-677)) and hGHRH(1-44) (Human growth hormone-releasing hormone (1-44) amide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Ibutamoren | hGHRH(1-44) |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Ibutamoren mesylate (MK-677) | Human growth hormone-releasing hormone (1-44) amide |
| Molecular Weight | N/A | N/A |
| Half-Life | about 24 hours | 5-15 minutes |
| Amino Acids | N/A | 44 |
| Typical Dose | 10-25 mg/day | 0.1-1 mcg/kg |
| Route | Oral | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 120 |
| Research Status | Clinical | Clinical Research |
Ibutamoren Benefits
- ✓raises GH/IGF-1
- ✓increases appetite
- ✓supports lean mass retention
- ✓oral non-peptide secretagogue
hGHRH(1-44) Benefits
- ✓physiologic GH pulse support
- ✓IGF-1 pathway stimulation
- ✓pituitary receptor mapping
- ✓endocrine research tool
Ibutamoren Dosing
10-25 mg orally once daily|take consistently at the same time each day|monitor fasting glucose and edema in longer studies
hGHRH(1-44) Dosing
0.1-1 mcg/kg SC or IV bolus for stimulation studies|single-dose endocrine challenge with timed GH sampling|pulsatile administration in clamp/infusion experiments
Ibutamoren Side Effects
- ⚠increased appetite
- ⚠water retention/edema
- ⚠somnolence or lethargy
hGHRH(1-44) Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient nausea
Research Overview
Ibutamoren
Clinical studies show oral ibutamoren reliably elevates GH and IGF-1 over 24 hours with once-daily dosing. Body composition and appetite effects vary by population, and development has been limited by metabolic side effects.
hGHRH(1-44)
Human GHRH(1-44) amide has been used extensively to characterize hypothalamic control of pituitary somatotrophs and the downstream GH/IGF-1 axis. It remains a standard comparator in studies of GHRH agonism, secretion dynamics, and receptor pharmacology.
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