hGHRH(1-44) vs hGHRH(1-40)OH
Head-to-head comparison of hGHRH(1-44) (Human growth hormone-releasing hormone (1-44) amide) and hGHRH(1-40)OH (Human growth hormone-releasing factor (1-40) hydroxyl) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | hGHRH(1-44) | hGHRH(1-40)OH |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Human growth hormone-releasing hormone (1-44) amide | Human growth hormone-releasing factor (1-40) hydroxyl |
| Molecular Weight | N/A | N/A |
| Half-Life | 5-15 minutes | 5-20 minutes |
| Amino Acids | 44 | 40 |
| Typical Dose | 0.1-1 mcg/kg | 1-2 mcg/kg |
| Route | Subcutaneous/IV | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 85 |
| Research Status | Clinical Research | Clinical Research |
hGHRH(1-44) Benefits
- ✓physiologic GH pulse support
- ✓IGF-1 pathway stimulation
- ✓pituitary receptor mapping
- ✓endocrine research tool
hGHRH(1-40)OH Benefits
- ✓GH secretion research
- ✓fragment-activity comparison
- ✓receptor binding studies
- ✓axis physiology modeling
hGHRH(1-44) Dosing
0.1-1 mcg/kg SC or IV bolus for stimulation studies|single-dose endocrine challenge with timed GH sampling|pulsatile administration in clamp/infusion experiments
hGHRH(1-40)OH Dosing
1-2 mcg/kg SC or IV in acute research settings|single-bolus GH stimulation protocols|repeated low-dose administration in comparative studies
hGHRH(1-44) Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient nausea
hGHRH(1-40)OH Side Effects
- ⚠flushing
- ⚠headache
- ⚠lightheadedness
Research Overview
hGHRH(1-44)
Human GHRH(1-44) amide has been used extensively to characterize hypothalamic control of pituitary somatotrophs and the downstream GH/IGF-1 axis. It remains a standard comparator in studies of GHRH agonism, secretion dynamics, and receptor pharmacology.
hGHRH(1-40)OH
Human GHRF(1-40)OH has been studied to understand how truncation of the native hormone changes biological potency and half-life. It is a common research tool for mapping minimal active sequences within the GHRH family.
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