hGHRH(1-44) vs Capromorelin
Head-to-head comparison of hGHRH(1-44) (Human growth hormone-releasing hormone (1-44) amide) and Capromorelin (Capromorelin hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | hGHRH(1-44) | Capromorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Human growth hormone-releasing hormone (1-44) amide | Capromorelin hydrochloride |
| Molecular Weight | N/A | N/A |
| Half-Life | 5-15 minutes | about 2-3 hours |
| Amino Acids | 44 | N/A |
| Typical Dose | 0.1-1 mcg/kg | 0.25-2 mg/kg/day |
| Route | Subcutaneous/IV | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 120 | 55 |
| Research Status | Clinical Research | Clinical |
hGHRH(1-44) Benefits
- ✓physiologic GH pulse support
- ✓IGF-1 pathway stimulation
- ✓pituitary receptor mapping
- ✓endocrine research tool
Capromorelin Benefits
- ✓GH secretagogue activity
- ✓appetite stimulation
- ✓oral administration
- ✓translational animal model utility
hGHRH(1-44) Dosing
0.1-1 mcg/kg SC or IV bolus for stimulation studies|single-dose endocrine challenge with timed GH sampling|pulsatile administration in clamp/infusion experiments
Capromorelin Dosing
0.25-2 mg/kg orally in studies|once-daily or protocol-specific dosing|monitor appetite and body weight
hGHRH(1-44) Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient nausea
Capromorelin Side Effects
- ⚠increased appetite
- ⚠vomiting or nausea
- ⚠lethargy
Research Overview
hGHRH(1-44)
Human GHRH(1-44) amide has been used extensively to characterize hypothalamic control of pituitary somatotrophs and the downstream GH/IGF-1 axis. It remains a standard comparator in studies of GHRH agonism, secretion dynamics, and receptor pharmacology.
Capromorelin
Research consistently shows capromorelin activates the ghrelin receptor pathway and increases food intake. Human development has been less prominent than veterinary use, but the compound remains a relevant GH secretagogue prototype.
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