Capromorelin vs Modified GRF(1-29)
Head-to-head comparison of Capromorelin (Capromorelin hydrochloride) and Modified GRF(1-29) ([D-Ala2, Nle27]-human growth hormone-releasing hormone (1-29) amide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Capromorelin | Modified GRF(1-29) |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Capromorelin hydrochloride | [D-Ala2, Nle27]-human growth hormone-releasing hormone (1-29) amide |
| Molecular Weight | N/A | N/A |
| Half-Life | about 2-3 hours | 10-30 minutes |
| Amino Acids | N/A | 29 |
| Typical Dose | 0.25-2 mg/kg/day | 50-300 mcg |
| Route | Oral | Subcutaneous |
| Purity | ≥98% | ≥98% |
| Studies Count | 55 | 150 |
| Research Status | Clinical | Investigational |
Capromorelin Benefits
- ✓GH secretagogue activity
- ✓appetite stimulation
- ✓oral administration
- ✓translational animal model utility
Modified GRF(1-29) Benefits
- ✓enhanced GH release
- ✓greater peptide stability
- ✓IGF-1 support research
- ✓longer receptor engagement
Capromorelin Dosing
0.25-2 mg/kg orally in studies|once-daily or protocol-specific dosing|monitor appetite and body weight
Modified GRF(1-29) Dosing
50-100 mcg SC for acute GH-response studies|100-300 mcg SC in monitored research protocols|repeat dosing in short investigative cycles with GH/IGF-1 tracking
Capromorelin Side Effects
- ⚠increased appetite
- ⚠vomiting or nausea
- ⚠lethargy
Modified GRF(1-29) Side Effects
- ⚠headache
- ⚠water retention
- ⚠injection-site irritation
Research Overview
Capromorelin
Research consistently shows capromorelin activates the ghrelin receptor pathway and increases food intake. Human development has been less prominent than veterinary use, but the compound remains a relevant GH secretagogue prototype.
Modified GRF(1-29)
Modified GRF(1-29) has been studied as a practical GHRH analog for boosting GH release while improving peptide stability versus the native fragment. It is a standard reference compound in experimental work on growth hormone pulsatility and analog design.
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