Modified GRF(1-29) vs hGHRH(1-32)NH2
Head-to-head comparison of Modified GRF(1-29) ([D-Ala2, Nle27]-human growth hormone-releasing hormone (1-29) amide) and hGHRH(1-32)NH2 (Human growth hormone-releasing factor (1-32) amide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Modified GRF(1-29) | hGHRH(1-32)NH2 |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | [D-Ala2, Nle27]-human growth hormone-releasing hormone (1-29) amide | Human growth hormone-releasing factor (1-32) amide |
| Molecular Weight | N/A | N/A |
| Half-Life | 10-30 minutes | 5-15 minutes |
| Amino Acids | 29 | 32 |
| Typical Dose | 50-300 mcg | 0.1-1 mcg/kg |
| Route | Subcutaneous | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 150 | 50 |
| Research Status | Investigational | Clinical Research |
Modified GRF(1-29) Benefits
- ✓enhanced GH release
- ✓greater peptide stability
- ✓IGF-1 support research
- ✓longer receptor engagement
hGHRH(1-32)NH2 Benefits
- ✓GH pulse induction
- ✓core-sequence testing
- ✓receptor signaling studies
- ✓protease-resistance comparisons
Modified GRF(1-29) Dosing
50-100 mcg SC for acute GH-response studies|100-300 mcg SC in monitored research protocols|repeat dosing in short investigative cycles with GH/IGF-1 tracking
hGHRH(1-32)NH2 Dosing
0.1-1 mcg/kg SC or IV bolus|acute GH-response testing with timed blood draws|pulsatile dosing in receptor studies
Modified GRF(1-29) Side Effects
- ⚠headache
- ⚠water retention
- ⚠injection-site irritation
hGHRH(1-32)NH2 Side Effects
- ⚠headache
- ⚠flushing
- ⚠injection-site irritation
Research Overview
Modified GRF(1-29)
Modified GRF(1-29) has been studied as a practical GHRH analog for boosting GH release while improving peptide stability versus the native fragment. It is a standard reference compound in experimental work on growth hormone pulsatility and analog design.
hGHRH(1-32)NH2
Human GHRF(1-32)NH2 is used in basic and translational studies to evaluate how the active N-terminal region of GHRH drives pituitary hormone release. It helps define the lower bound of sequence length needed for meaningful biological activity.
Ready to buy?
Find both peptides from our verified, lab-tested vendors with purity certificates and third-party testing.