Modified GRF(1-29) vs Capromorelin
Head-to-head comparison of Modified GRF(1-29) ([D-Ala2, Nle27]-human growth hormone-releasing hormone (1-29) amide) and Capromorelin (Capromorelin hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Modified GRF(1-29) | Capromorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | [D-Ala2, Nle27]-human growth hormone-releasing hormone (1-29) amide | Capromorelin hydrochloride |
| Molecular Weight | N/A | N/A |
| Half-Life | 10-30 minutes | about 2-3 hours |
| Amino Acids | 29 | N/A |
| Typical Dose | 50-300 mcg | 0.25-2 mg/kg/day |
| Route | Subcutaneous | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 150 | 55 |
| Research Status | Investigational | Clinical |
Modified GRF(1-29) Benefits
- ✓enhanced GH release
- ✓greater peptide stability
- ✓IGF-1 support research
- ✓longer receptor engagement
Capromorelin Benefits
- ✓GH secretagogue activity
- ✓appetite stimulation
- ✓oral administration
- ✓translational animal model utility
Modified GRF(1-29) Dosing
50-100 mcg SC for acute GH-response studies|100-300 mcg SC in monitored research protocols|repeat dosing in short investigative cycles with GH/IGF-1 tracking
Capromorelin Dosing
0.25-2 mg/kg orally in studies|once-daily or protocol-specific dosing|monitor appetite and body weight
Modified GRF(1-29) Side Effects
- ⚠headache
- ⚠water retention
- ⚠injection-site irritation
Capromorelin Side Effects
- ⚠increased appetite
- ⚠vomiting or nausea
- ⚠lethargy
Research Overview
Modified GRF(1-29)
Modified GRF(1-29) has been studied as a practical GHRH analog for boosting GH release while improving peptide stability versus the native fragment. It is a standard reference compound in experimental work on growth hormone pulsatility and analog design.
Capromorelin
Research consistently shows capromorelin activates the ghrelin receptor pathway and increases food intake. Human development has been less prominent than veterinary use, but the compound remains a relevant GH secretagogue prototype.
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