Modified GRF(1-29) vs Macimorelin
Head-to-head comparison of Modified GRF(1-29) ([D-Ala2, Nle27]-human growth hormone-releasing hormone (1-29) amide) and Macimorelin (Macimorelin acetate (AEZS-130)) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Modified GRF(1-29) | Macimorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | [D-Ala2, Nle27]-human growth hormone-releasing hormone (1-29) amide | Macimorelin acetate (AEZS-130) |
| Molecular Weight | N/A | N/A |
| Half-Life | 10-30 minutes | about 4-6 hours |
| Amino Acids | 29 | N/A |
| Typical Dose | 50-300 mcg | 0.5 mg/kg single oral dose |
| Route | Subcutaneous | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 150 | 120 |
| Research Status | Investigational | Clinical |
Modified GRF(1-29) Benefits
- ✓enhanced GH release
- ✓greater peptide stability
- ✓IGF-1 support research
- ✓longer receptor engagement
Macimorelin Benefits
- ✓diagnostic GH stimulation
- ✓single oral dose
- ✓rapid measurable GH response
- ✓high clinical utility
Modified GRF(1-29) Dosing
50-100 mcg SC for acute GH-response studies|100-300 mcg SC in monitored research protocols|repeat dosing in short investigative cycles with GH/IGF-1 tracking
Macimorelin Dosing
0.5 mg/kg orally as a single dose|fasted testing conditions|serial GH sampling after administration
Modified GRF(1-29) Side Effects
- ⚠headache
- ⚠water retention
- ⚠injection-site irritation
Macimorelin Side Effects
- ⚠dysgeusia or taste disturbance
- ⚠nausea
- ⚠headache
Research Overview
Modified GRF(1-29)
Modified GRF(1-29) has been studied as a practical GHRH analog for boosting GH release while improving peptide stability versus the native fragment. It is a standard reference compound in experimental work on growth hormone pulsatility and analog design.
Macimorelin
Macimorelin has been validated in clinical testing as an oral alternative to injectable GH stimulation tests. Its short-term use makes it a useful translational tool for evaluating pituitary GH reserve.
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