C-peptide vs hGHRH(1-44)
Head-to-head comparison of C-peptide (Connecting peptide (C-peptide)) and hGHRH(1-44) (Human growth hormone-releasing hormone (1-44) amide) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | C-peptide | hGHRH(1-44) |
|---|---|---|
| Category | Pain Management | Growth Hormone |
| Full Name | Connecting peptide (C-peptide) | Human growth hormone-releasing hormone (1-44) amide |
| Molecular Weight | 3020.3 Da | N/A |
| Half-Life | ~20-30 min | 5-15 minutes |
| Amino Acids | 31 | 44 |
| Typical Dose | no approved analgesic dose|research-only | 0.1-1 mcg/kg |
| Route | IV|subQ | Subcutaneous/IV |
| Purity | ≥98% | ≥98% |
| Studies Count | 46 | 120 |
| Research Status | Pre-clinical | Clinical Research |
C-peptide Benefits
- ✓diabetic neuropathy research
- ✓nerve function support
- ✓possible analgesic effect
hGHRH(1-44) Benefits
- ✓physiologic GH pulse support
- ✓IGF-1 pathway stimulation
- ✓pituitary receptor mapping
- ✓endocrine research tool
C-peptide Dosing
0.5-1.0 mg/day in research|route varies by protocol
hGHRH(1-44) Dosing
0.1-1 mcg/kg SC or IV bolus for stimulation studies|single-dose endocrine challenge with timed GH sampling|pulsatile administration in clamp/infusion experiments
C-peptide Side Effects
- ⚠injection-site reactions
- ⚠unknown long-term safety
hGHRH(1-44) Side Effects
- ⚠flushing
- ⚠headache
- ⚠transient nausea
Research Overview
C-peptide
C-peptide is not an approved analgesic, but multiple studies have examined its effects on peripheral nerve blood flow and neuropathy outcomes. The strongest relevance is in diabetic neuropathic pain rather than migraine.
hGHRH(1-44)
Human GHRH(1-44) amide has been used extensively to characterize hypothalamic control of pituitary somatotrophs and the downstream GH/IGF-1 axis. It remains a standard comparator in studies of GHRH agonism, secretion dynamics, and receptor pharmacology.
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