MK-677 vs Capromorelin
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and Capromorelin (Capromorelin hydrochloride) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | MK-677 | Capromorelin |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Ibutamoren Mesylate (MK-677) | Capromorelin hydrochloride |
| Molecular Weight | 528.662 g/mol | N/A |
| Half-Life | ~24 hours | about 2-3 hours |
| Amino Acids | Non-peptide compound | N/A |
| Typical Dose | — | 0.25-2 mg/kg/day |
| Route | — | Oral |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 55 |
| Research Status | Active Research | Clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
Capromorelin Benefits
- ✓GH secretagogue activity
- ✓appetite stimulation
- ✓oral administration
- ✓translational animal model utility
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
Capromorelin Dosing
0.25-2 mg/kg orally in studies|once-daily or protocol-specific dosing|monitor appetite and body weight
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
Capromorelin Side Effects
- ⚠increased appetite
- ⚠vomiting or nausea
- ⚠lethargy
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
Capromorelin
Research consistently shows capromorelin activates the ghrelin receptor pathway and increases food intake. Human development has been less prominent than veterinary use, but the compound remains a relevant GH secretagogue prototype.
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