MK-677 vs L-692,429
Head-to-head comparison of MK-677 (Ibutamoren Mesylate (MK-677)) and L-692,429 (L-692,429) — benefits, dosing, side effects, research data, and where to buy.
| Property | MK-677 | L-692,429 |
|---|---|---|
| Category | Growth Hormone | Growth Hormone |
| Full Name | Ibutamoren Mesylate (MK-677) | L-692,429 |
| Molecular Weight | 528.662 g/mol | N/A |
| Half-Life | ~24 hours | unknown / study-dependent |
| Amino Acids | Non-peptide compound | N/A |
| Typical Dose | — | 0.03-0.1 mg/kg |
| Route | — | Oral |
| Purity | >99% | ≥98% |
| Studies Count | 120 | 30 |
| Research Status | Active Research | Pre-clinical |
MK-677 Benefits
- ✓Oral GH secretagogue, 24-hour GH elevation, increases IGF-1, improves sleep quality, increases lean mass, does not suppress natural GH
L-692,429 Benefits
- ✓potent GHSR agonism
- ✓oral bioactivity in models
- ✓validates ghrelin pathway
- ✓useful research probe
MK-677 Dosing
10-25 mg orally once daily before bedtime. 25 mg is the most studied dose. Can be used long-term without cycling.
L-692,429 Dosing
0.03-0.1 mg/kg in early studies|single oral or short-course research dosing|serial GH sampling recommended
MK-677 Side Effects
- ⚠Increased appetite, mild water retention, drowsiness, transient numbness, mild increase in fasting blood glucose with long-term use.
L-692,429 Side Effects
- ⚠increased appetite
- ⚠glucose intolerance
- ⚠transient prolactin changes
Research Overview
MK-677
A landmark 2-year study in elderly adults demonstrated significant increases in lean mass, GH pulsatility, and IGF-1 to youthful ranges. Selectively agonizes GHS-R1a without increasing cortisol or prolactin.
L-692,429
L-692,429 was important in early GH secretagogue research because it showed that nonpeptide molecules could trigger robust GH release. It remains a classic tool compound for studying receptor-mediated GH pulsatility and appetite signaling.
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