Metformin vs Melatonin
Head-to-head comparison of Metformin (Metformin Hydrochloride) and Melatonin (N-acetyl-5-methoxytryptamine) — benefits, dosing, side effects, research data, and where to buy.
| Property | Metformin | Melatonin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | Metformin Hydrochloride | N-acetyl-5-methoxytryptamine |
| Molecular Weight | 165.63 Da | 232.28 Da |
| Half-Life | 4-8.7 hours | 20-50 minutes |
| Amino Acids | N/A | 0 |
| Typical Dose | 500-2000 mg/day | — |
| Route | Oral | — |
| Purity | ≥98% | ≥98% |
| Studies Count | 4000 | 15000 |
| Research Status | Clinical | Approved |
Metformin Benefits
- ✓AMPK activation
- ✓improved insulin sensitivity
- ✓reduced oxidative stress
- ✓population-level longevity signal
Melatonin Benefits
- ✓Sleep regulation, circadian rhythm restoration, antioxidant protection, immune system support, potential neuroprotection, anti-aging effects
Metformin Dosing
500-2000 mg/day oral|start low and titrate in trials|taken with meals
Melatonin Dosing
0.5-10mg orally, typically 30-60 minutes before desired sleep time. Lower doses (0.5-3mg) often more effective for sleep onset
Metformin Side Effects
- ⚠gastrointestinal upset
- ⚠vitamin B12 reduction
- ⚠diarrhea
- ⚠rare lactic acidosis
Melatonin Side Effects
- ⚠Drowsiness, headache, dizziness, nausea, vivid dreams, potential hormone interactions, daytime fatigue with higher doses
Research Overview
Metformin
Metformin has extensive human data and remains a leading candidate in geroscience research. Observational and mechanistic studies suggest it may influence pathways tied to aging, though definitive anti-longevity proof in healthy humans is still lacking.
Melatonin
Melatonin has extensive clinical research supporting its efficacy for sleep disorders, jet lag, and shift work sleep disorder. Emerging research investigates its potential anti-aging, neuroprotective, and immune-modulating properties with promising preliminary results.
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