Melatonin vs Fisetin
Head-to-head comparison of Melatonin (N-acetyl-5-methoxytryptamine) and Fisetin (3,3',4',7-Tetrahydroxyflavone) — benefits, dosing, side effects, research data, and where to buy.
| Property | Melatonin | Fisetin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | N-acetyl-5-methoxytryptamine | 3,3',4',7-Tetrahydroxyflavone |
| Molecular Weight | 232.28 Da | 286.24 Da |
| Half-Life | 20-50 minutes | 3-8 hours |
| Amino Acids | 0 | N/A |
| Typical Dose | — | 1000-2000 mg/day |
| Route | — | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 15000 | 180 |
| Research Status | Approved | Pre-clinical |
Melatonin Benefits
- ✓Sleep regulation, circadian rhythm restoration, antioxidant protection, immune system support, potential neuroprotection, anti-aging effects
Fisetin Benefits
- ✓senolytic activity
- ✓reduces inflammatory signaling
- ✓supports mitochondrial function
- ✓may improve healthspan
Melatonin Dosing
0.5-10mg orally, typically 30-60 minutes before desired sleep time. Lower doses (0.5-3mg) often more effective for sleep onset
Fisetin Dosing
1000-2000 mg/day orally|1-2 days per month in senolytic-style studies|take with a fat-containing meal
Melatonin Side Effects
- ⚠Drowsiness, headache, dizziness, nausea, vivid dreams, potential hormone interactions, daytime fatigue with higher doses
Fisetin Side Effects
- ⚠GI upset
- ⚠headache
- ⚠possible blood-thinner interaction
Research Overview
Melatonin
Melatonin has extensive clinical research supporting its efficacy for sleep disorders, jet lag, and shift work sleep disorder. Emerging research investigates its potential anti-aging, neuroprotective, and immune-modulating properties with promising preliminary results.
Fisetin
Preclinical studies show fisetin can selectively target senescent cells and reduce age-related inflammatory markers. Early human research exists, but definitive anti-aging outcomes in humans are still unproven.
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