Fisetin vs Urolithin A
Head-to-head comparison of Fisetin (3,3',4',7-Tetrahydroxyflavone) and Urolithin A (Urolithin A) — benefits, dosing, side effects, research data, and where to buy.
Research Score
| Property | Fisetin | Urolithin A |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | 3,3',4',7-Tetrahydroxyflavone | Urolithin A |
| Molecular Weight | 286.24 Da | 228.20 Da |
| Half-Life | 3-8 hours | N/A |
| Amino Acids | N/A | N/A |
| Typical Dose | 1000-2000 mg/day | 250-1000 mg/day |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 120 |
| Research Status | Pre-clinical | Clinical |
Fisetin Benefits
- ✓senolytic activity
- ✓reduces inflammatory signaling
- ✓supports mitochondrial function
- ✓may improve healthspan
Urolithin A Benefits
- ✓mitophagy activation
- ✓muscle endurance support
- ✓mitochondrial health
- ✓cellular cleanup
Fisetin Dosing
1000-2000 mg/day orally|1-2 days per month in senolytic-style studies|take with a fat-containing meal
Urolithin A Dosing
250-1000 mg/day oral|daily capsule dosing in studies|single daily dose protocols
Fisetin Side Effects
- ⚠GI upset
- ⚠headache
- ⚠possible blood-thinner interaction
Urolithin A Side Effects
- ⚠nausea
- ⚠GI discomfort
- ⚠headache
- ⚠bloating
Research Overview
Fisetin
Preclinical studies show fisetin can selectively target senescent cells and reduce age-related inflammatory markers. Early human research exists, but definitive anti-aging outcomes in humans are still unproven.
Urolithin A
Urolithin A has both animal and human data showing effects on mitochondrial biomarkers and physical performance-related endpoints. It is one of the more promising mitochondrial-targeted longevity compounds in current literature.
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