Fisetin vs Rapamycin
Head-to-head comparison of Fisetin (3,3',4',7-Tetrahydroxyflavone) and Rapamycin (Rapamycin (Sirolimus)) — benefits, dosing, side effects, research data, and where to buy.
| Property | Fisetin | Rapamycin |
|---|---|---|
| Category | Anti-Aging | Anti-Aging |
| Full Name | 3,3',4',7-Tetrahydroxyflavone | Rapamycin (Sirolimus) |
| Molecular Weight | 286.24 Da | 914.17 Da |
| Half-Life | 3-8 hours | ~62 hours |
| Amino Acids | N/A | N/A |
| Typical Dose | 1000-2000 mg/day | 0.5-6 mg/week |
| Route | Oral | Oral |
| Purity | ≥98% | ≥98% |
| Studies Count | 180 | 1500 |
| Research Status | Pre-clinical | Clinical |
Fisetin Benefits
- ✓senolytic activity
- ✓reduces inflammatory signaling
- ✓supports mitochondrial function
- ✓may improve healthspan
Rapamycin Benefits
- ✓mTOR inhibition
- ✓autophagy activation
- ✓cellular senescence modulation
- ✓lifespan extension in model organisms
Fisetin Dosing
1000-2000 mg/day orally|1-2 days per month in senolytic-style studies|take with a fat-containing meal
Rapamycin Dosing
0.5-6 mg oral weekly in studies|intermittent dosing protocols|clinical monitoring for tolerability
Fisetin Side Effects
- ⚠GI upset
- ⚠headache
- ⚠possible blood-thinner interaction
Rapamycin Side Effects
- ⚠mouth ulcers
- ⚠elevated lipids
- ⚠immunosuppression
- ⚠glucose intolerance
Research Overview
Fisetin
Preclinical studies show fisetin can selectively target senescent cells and reduce age-related inflammatory markers. Early human research exists, but definitive anti-aging outcomes in humans are still unproven.
Rapamycin
Rapamycin extends lifespan in multiple model organisms and is a cornerstone compound in longevity biology. Human studies focus on immune function, inflammation, and age-related biomarkers rather than proven lifespan extension.
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