Rapamycin
Rapamycin (Sirolimus)
N/A Amino Acids · MW: 914.17 Da
Amino Acids
N/A
Molecular Weight
914.17 Da
Half-life
~62 hours
Research Score
4.9
Studies
1500
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Rapamycin?
Rapamycin is a macrolide originally developed as an immunosuppressant and is one of the most studied geroscience compounds. In aging research, it is best known for inhibiting mTOR, a pathway strongly linked to nutrient sensing, autophagy, and lifespan regulation.
Key Benefits & Mechanisms
mTOR inhibition
autophagy activation
cellular senescence modulation
lifespan extension in model organisms
Research Summary
Rapamycin extends lifespan in multiple model organisms and is a cornerstone compound in longevity biology. Human studies focus on immune function, inflammation, and age-related biomarkers rather than proven lifespan extension.
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