Metformin
Metformin Hydrochloride
N/A Amino Acids · MW: 165.63 Da
Amino Acids
N/A
Molecular Weight
165.63 Da
Half-life
4-8.7 hours
Research Score
4.8
Studies
4000
Storage
Store lyophilized at -20°C, reconstituted at 2-8°C
What is Metformin?
Metformin is a biguanide widely used for type 2 diabetes and heavily studied for geroprotection. Its anti-aging interest comes from effects on AMPK signaling, insulin sensitivity, inflammation, and cellular stress responses.
Key Benefits & Mechanisms
AMPK activation
improved insulin sensitivity
reduced oxidative stress
population-level longevity signal
Research Summary
Metformin has extensive human data and remains a leading candidate in geroscience research. Observational and mechanistic studies suggest it may influence pathways tied to aging, though definitive anti-longevity proof in healthy humans is still lacking.
Related Peptides
Rapamycin
Rapamycin (Sirolimus)
Rapamycin is a macrolide originally developed as an immunosuppressant and is one of the most studied geroscience compounds. In aging research, it is best known for inhibiting mTOR, a pathway strongly linked to nutrient sensing, autophagy, and lifespan regulation.
Anti-AgingNMN
Nicotinamide Mononucleotide
Nicotinamide mononucleotide is a direct NAD+ precursor studied for age-associated declines in cellular energy and repair processes. It is commonly researched in the context of mitochondrial function, DNA repair support, and metabolic resilience.
Anti-AgingSpermidine
Spermidine
Spermidine is a naturally occurring polyamine found in cells and foods such as wheat germ and soy. It is studied for its ability to promote autophagy and support cellular maintenance pathways that decline with age.
Anti-AgingUrolithin A
Urolithin A
Urolithin A is a gut-microbiome-derived metabolite of ellagitannins that has become a serious research compound in aging biology. It is studied for mitochondrial quality control, mitophagy, and muscle function in older adults.
Anti-Aging